Adding Variants to Reports

This guide explains how to add variants to clinical reports in VariantMiner, including selection criteria, interpretation, and management of variants within reports.

Overview

Adding variants to reports involves:

• Variant Selection: Choosing clinically relevant variants

• Clinical Interpretation: Providing pathogenicity assessment

• Evidence Documentation: Supporting clinical significance

• Report Integration: Incorporating variants into structured reports

Selection Methods

From Variant Browser

1. Filter Variants: Apply clinical filters to identify candidates

2. Review Details: Examine variant annotations and evidence

3. Select Variants: Use checkboxes to select relevant variants

4. Add to Report: Click "Add to Report" button

From Analysis Results

1. Review Analysis: Examine completed analysis results

2. Prioritize Findings: Focus on high-impact, rare variants

3. Clinical Correlation: Match variants to patient phenotype

4. Bulk Addition: Add multiple variants simultaneously

Variant Interpretation

ACMG Classification

• Apply appropriate pathogenicity classification

• Document supporting evidence criteria

• Justify classification decisions

• Reference supporting literature

Clinical Significance

• Assess relevance to patient phenotype

• Consider penetrance and expressivity

• Evaluate treatment implications

• Document recommendations

Managing Report Variants

Organization

• Group variants by gene or functional pathway

• Prioritize by clinical significance

• Separate primary from incidental findings

• Maintain consistent formatting

Review Process

• Technical review for accuracy

• Clinical review for interpretation

• Administrative review for completeness

• Final approval before delivery

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Continue to Report Templates to learn about using and customizing report formats.